1,3,2-Dioxaborolane, 2-butyl-4,4,5,5-tetramethyl-

1,3,2-Dioxaborolane, 2-butyl-4,4,5,5-tetramethyl- - Names and Identifiers

Name	2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Synonyms	N-BUTYLBORONIC ACID, PINACOL ESTER But-1-ylboronic acid, pinacol ester Butane-1-boronic acid, pinacol ester 2-BUTYL-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1,3,2-Dioxaborolane, 2-butyl-4,4,5,5-tetramethyl-
CAS	69190-62-1
InChI	InChI=1/C10H21BO2/c1-6-7-8-11-12-9(2,3)10(4,5)13-11/h6-8H2,1-5H3

1,3,2-Dioxaborolane, 2-butyl-4,4,5,5-tetramethyl- - Physico-chemical Properties

Molecular Formula	C10H21BO2
Molar Mass	184.08
Density	0.865
Boling Point	185-189
Flash Point	58°C
Vapor Presure	0.532mmHg at 25°C
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.4182

1,3,2-Dioxaborolane, 2-butyl-4,4,5,5-tetramethyl- - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes.
UN IDs	UN 1993 3/PG 3
WGK Germany	3
HS Code	29319090

1,3,2-Dioxaborolane, 2-butyl-4,4,5,5-tetramethyl- - Upstream Downstream Industry

Raw Materials	Boronic acid, butyl-, dimethyl ester TRIPHENYLTIN HYDRIDE 2-(4-broMobutyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane 1,3,2-Dioxaborolan-2-amine, N,N,4,4,5,5-hexamethyl- DI-N-BUTYLMAGNESIUM Pinacol 1-Chlorobutane CIS-2-BUTENE 1-Bromobutane Pinacolborane
Downstream Products	n-Butylboronic acid 1-HEPTEN-3-OL

1,3,2-Dioxaborolane, 2-butyl-4,4,5,5-tetramethyl- - Introduction

2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is an organic compound whose chemical formula is C12H25BO2. The following is a description of its nature, use, preparation and safety information:

Nature:
2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a liquid, colorless and transparent liquid at room temperature, with a low vapor pressure. It is insoluble in water, but soluble in many organic solvents, such as ethanol, acetone and dichloromethane. The compound is stable to air and light heat.

Use:
2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is an important organic boron reagent, which has a wide range of applications in organic synthesis. It can be used as a boron reagent to participate in a variety of reactions, such as Suzuki coupling reaction and C- H activation. In addition, it can also be used to prepare other organoboron compounds.

Preparation Method:
Generally, the preparation of 2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is obtained by reducing 2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane with magnesium iodide. The specific preparation method is as follows:
1.2-butyl -4,4,5,5-tetramethyl -1,3,2-dithiothiolane was prepared into 2-butyl -4,4,5,5-tetramethyl -1,3,2-dibromopentane by magnesium bromide;
2.2.2-butyl-4,4,5,5-tetramethyl-1,3,2-dibromopentane is reacted with 2,3-dioxybutyrate to generate 2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Safety Information:
Specific toxicity data for 2-butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane are currently lacking, but based on the information on related compounds, the following safety precautions should be noted:
-Contact with skin or inhalation of vapors may be harmful to health. When in use, wear appropriate breathing apparatus and personal protective equipment such as protective gloves and goggles to avoid direct contact or inhalation of the substance.
-Avoid exposure of the substance to fire and high temperature environments. This compound may cause a fire or explosion.
-When operating in the laboratory, it should be carried out in a well-ventilated place to avoid the accumulation of vapor.
-Follow all relevant safe practices and instructions when using, storing and handling the substance. If there is any doubt or unexpected situation, you should immediately consult a professional.

Last Update：2024-04-10 22:29:15